diff --git a/src/genlab_bestilling/migrations/0020_sample_is_prioritised.py b/src/genlab_bestilling/migrations/0020_sample_is_prioritised.py
index 3c431782..c9208b96 100644
--- a/src/genlab_bestilling/migrations/0020_sample_is_prioritised.py
+++ b/src/genlab_bestilling/migrations/0020_sample_is_prioritised.py
@@ -1,4 +1,4 @@
-# Generated by Django 5.2.3 on 2025-07-07 06:40
+# Generated by Django 5.2.3 on 2025-07-07 09:53
 
 from django.db import migrations, models
 
diff --git a/src/genlab_bestilling/migrations/0022_sample_internal_note.py b/src/genlab_bestilling/migrations/0022_sample_internal_note.py
new file mode 100644
index 00000000..48249fe7
--- /dev/null
+++ b/src/genlab_bestilling/migrations/0022_sample_internal_note.py
@@ -0,0 +1,17 @@
+# Generated by Django 5.2.3 on 2025-07-07 13:25
+
+from django.db import migrations, models
+
+
+class Migration(migrations.Migration):
+    dependencies = [
+        ("genlab_bestilling", "0021_order_is_prioritized_order_is_seen"),
+    ]
+
+    operations = [
+        migrations.AddField(
+            model_name="sample",
+            name="internal_note",
+            field=models.TextField(blank=True, null=True),
+        ),
+    ]
diff --git a/src/genlab_bestilling/models.py b/src/genlab_bestilling/models.py
index cf094cc1..cbc645f0 100644
--- a/src/genlab_bestilling/models.py
+++ b/src/genlab_bestilling/models.py
@@ -634,6 +634,9 @@ class Sample(models.Model):
     species = models.ForeignKey(f"{an}.Species", on_delete=models.PROTECT)
     year = models.IntegerField()
     notes = models.TextField(null=True, blank=True)
+
+    # "Merknad" in the Excel sheet.
+    internal_note = models.TextField(null=True, blank=True)
     pop_id = models.CharField(max_length=150, null=True, blank=True)
     location = models.ForeignKey(
         f"{an}.Location", on_delete=models.PROTECT, null=True, blank=True
diff --git a/src/staff/tables.py b/src/staff/tables.py
index 43066242..2f7f42a0 100644
--- a/src/staff/tables.py
+++ b/src/staff/tables.py
@@ -235,9 +235,14 @@ class CustomSampleTable(tables.Table):
                 default=False,
             )
 
+        internal_note = tables.TemplateColumn(
+            template_name="staff/note_input_column.html", orderable=False
+        )
+
         class Meta:
             model = Sample
-            fields = ["checked", "genlab_id"] + list(base_fields)
+            fields = ["checked", "genlab_id", "internal_note"] + list(base_fields)
+            sequence = ["checked", "genlab_id"] + list(base_fields) + ["internal_note"]
 
     return CustomSampleTable
 
diff --git a/src/staff/templates/staff/note_input_column.html b/src/staff/templates/staff/note_input_column.html
new file mode 100644
index 00000000..c98206c3
--- /dev/null
+++ b/src/staff/templates/staff/note_input_column.html
@@ -0,0 +1,7 @@
+<textarea
+    id="internal_note-input-{{ record.pk }}"
+    class="internal_note-input w-52 px-2.5 py-1.5 text-sm border border-gray-300 rounded-lg resize-none placeholder:text-gray-400 placeholder:italic"
+    data-sample-id="{{ record.pk }}"
+    placeholder="Write a note..."
+>{{ record.internal_note|default:'' }}
+</textarea>
diff --git a/src/staff/templates/staff/sample_lab.html b/src/staff/templates/staff/sample_lab.html
index 6994df77..84752049 100644
--- a/src/staff/templates/staff/sample_lab.html
+++ b/src/staff/templates/staff/sample_lab.html
@@ -24,17 +24,37 @@ <h3 class="text-4xl mb-5">{% block page-title %}{% if order %}{{ order }} - Samp
 
 {% block body_javascript %}
 <script>
-    document.addEventListener('DOMContentLoaded', function() {
+    document.addEventListener("DOMContentLoaded", function () {
         const selectAll = document.getElementById('select-all-checkbox');
-        if(selectAll) {
-            selectAll.addEventListener('input', function() {
-                const checkboxes = document.querySelectorAll('input[type="checkbox"]');
-                checkboxes.forEach(cb => {
-                    cb.checked = selectAll.checked;
-                })
+        const noteInputs = document.querySelectorAll('.internal_note-input');
+
+        selectAll?.addEventListener('change', function() {
+            const checkboxes = document.querySelectorAll('input[type="checkbox"]');
+            checkboxes.forEach((cb) => {
+                cb.checked = selectAll.checked;
+            })
+        });
+
+        let debounceTimeout;
+        noteInputs.forEach(function (noteInput) {
+            noteInput.addEventListener("input", function (event) {
+                const sampleId = event.target.dataset.sampleId;
+                const value = event.target.value;
+                const formData = new FormData();
+                formData.append("sample_id", sampleId);
+                formData.append("field_name", "internal_note-input");
+                formData.append("field_value", value);
+                formData.append("csrfmiddlewaretoken", "{{ csrf_token }}");
+
+                clearTimeout(debounceTimeout);
+                debounceTimeout = setTimeout(function () {
+                    fetch("{% url 'staff:update-sample' %}", {
+                        method: "POST",
+                        body: formData
+                    });
+                }, 500);
             });
-        }
+        });
     });
 </script>
-
-{% endblock body_javascript %}
+{% endblock body_javascript%}
diff --git a/src/staff/urls.py b/src/staff/urls.py
index 46c8ba5a..07a7e696 100644
--- a/src/staff/urls.py
+++ b/src/staff/urls.py
@@ -27,6 +27,7 @@
     SampleLabView,
     SampleReplicaActionView,
     SamplesListView,
+    UpdateLabViewFields,
 )
 
 app_name = "staff"
@@ -93,6 +94,11 @@
         GenerateGenlabIDsView.as_view(),
         name="generate-genlab-ids",
     ),
+    path(
+        "orders/samples/update/",
+        UpdateLabViewFields.as_view(),
+        name="update-sample",
+    ),
     path(
         "orders/analysis/<int:pk>/samples/",
         OrderAnalysisSamplesListView.as_view(),
diff --git a/src/staff/views.py b/src/staff/views.py
index 74229087..6bc92bca 100644
--- a/src/staff/views.py
+++ b/src/staff/views.py
@@ -6,7 +6,7 @@
 from django.db import models
 from django.db.models import Count
 from django.forms import Form
-from django.http import HttpRequest, HttpResponse, HttpResponseRedirect
+from django.http import HttpRequest, HttpResponse, HttpResponseRedirect, JsonResponse
 from django.shortcuts import get_object_or_404
 from django.urls import reverse, reverse_lazy
 from django.utils.timezone import now
@@ -377,6 +377,27 @@ def post(self, request: HttpRequest, *args, **kwargs) -> HttpResponse:
         return HttpResponseRedirect(self.get_success_url())
 
 
+class UpdateLabViewFields(StaffMixin, ActionView):
+    def post(self, request: HttpRequest, *args, **kwargs) -> JsonResponse:
+        sample_id = request.POST.get("sample_id")
+        field_name = request.POST.get("field_name")
+        field_value = request.POST.get("field_value")
+
+        if not sample_id or not field_name or field_value is None:
+            return JsonResponse({"error": "Invalid input"}, status=400)
+
+        try:
+            sample = Sample.objects.get(id=sample_id)
+
+            if field_name == "internal_note-input":
+                sample.internal_note = field_value
+                sample.save()
+
+            return JsonResponse({"success": True})
+        except Sample.DoesNotExist:
+            return JsonResponse({"error": "Sample not found"}, status=404)
+
+
 class ManaullyCheckedOrderActionView(SingleObjectMixin, ActionView):
     model = ExtractionOrder