https://github.com/AlexandrovLab/SigProfilerPlotting/blob/db6d54ceb45ac8b6844efadd5175f30ad8333aaa/sigProfilerPlotting/sigProfilerPlotting.py#L6406 SBS4608 is throwing a ZeroDevisionError for me. I can see that you already have a checkpoint for `mutation_count_total` https://github.com/AlexandrovLab/SigProfilerPlotting/blob/db6d54ceb45ac8b6844efadd5175f30ad8333aaa/sigProfilerPlotting/sigProfilerPlotting.py#L6288, so the error was potentially because `ratio_total` is 0? I'm wondering if you could add some checkpoints for the relevant variables as well?