If you are experiencing failures with error messages of "Error occurred attempting to toggle DTR/RTS sequence for reset into bootloader" in the log, and are using a Chromium-based browser version 139.0.7258.66 on a POSIX-based platform (Linux, Mac, etc.), then unfortunately this is due to a browser bug.
This is not a bug in the Web ISP code, and will be resolved when the bug is fixed in the browser.
This bug does not affect Windows users.