📦 Request to Add Formula: mosdepth

[BenjaminDEMAILLE]

Hi Homebrew Science team,

I’d like to request the addition of a formula for mosdepth, a fast and memory-efficient tool for computing read depth from BAM/CRAM files.

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🔍 Tool Overview

• Name: mosdepth
• Repository: https://github.com/brentp/mosdepth
• License: MIT
• Language: Rust
• Platform: Cross-platform (Linux and macOS supported)
• Latest version: v0.3.5 (as of March 2025)
• Installation: Built using cargo

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💡 Why it’s useful

mosdepth is widely used in WGS/WES pipelines for:

• Calculating per-base, per-region, and per-window depth
• Fast coverage analysis for CNV detection, QC, and panel validation
• Handling large BAM/CRAM files efficiently using HTSlib and multi-threading

Compared to samtools depth, mosdepth is significantly faster and more memory-efficient, especially on modern multicore systems.

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✅ Proposed Formula

class Mosdepth < Formula
  desc "Fast BAM/CRAM depth calculation for WGS/WES"
  homepage "https://github.com/brentp/mosdepth"
  url "https://github.com/brentp/mosdepth/archive/refs/tags/v0.3.5.tar.gz"
  sha256 "<insert_sha256_here>"
  license "MIT"

  depends_on "rust" => :build

  def install
    system "cargo", "install", *std_cargo_args
  end

  test do
    assert_match "Usage", shell_output("#{bin}/mosdepth --help")
  end
end