diff --git a/CHANGELOG.md b/CHANGELOG.md
index ca36d20b5d..3229bbdb87 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -33,6 +33,7 @@ OpenTelemetry Go Automatic Instrumentation adheres to [Semantic Versioning](http
 - Cache offsets for `github.com/segmentio/kafka-go` `0.4.50`. ([#3213](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/3213))
 - Cache offsets for Go `1.24.12`. ([#3213](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/3213))
 - Cache offsets for Go `1.25.6`. ([#3213](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/3213))
+- Cache offsets for `google.golang.org/grpc` `1.80.0-dev`. ([#3232](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/3232))
 
 ### Removed
 
diff --git a/internal/pkg/inject/offset_results.json b/internal/pkg/inject/offset_results.json
index a166a06164..184c4d183d 100644
--- a/internal/pkg/inject/offset_results.json
+++ b/internal/pkg/inject/offset_results.json
@@ -2006,7 +2006,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -2251,7 +2252,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -2501,7 +2503,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -2751,7 +2754,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -2996,7 +3000,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -3246,7 +3251,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -3307,7 +3313,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   },
                   {
@@ -3756,7 +3763,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -3812,7 +3820,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   },
                   {
@@ -4266,7 +4275,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -4506,7 +4516,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -4745,7 +4756,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   },
                   {
@@ -5026,7 +5038,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]
@@ -5276,7 +5289,8 @@
                       "1.77.0",
                       "1.78.0-dev",
                       "1.78.0",
-                      "1.79.0-dev"
+                      "1.79.0-dev",
+                      "1.80.0-dev"
                     ]
                   }
                 ]