ACMG Assistant

• Added integration validation report (JSON/Markdown) with reference dataset checks
• Added optional ENA metadata validation (ENA Browser API)
• Expanded CLI end-to-end test coverage with mocked inputs
• Improved predictor/population fallbacks and cache keying for dataset variants
• Normalized applied criteria in reports and classification summaries
• Fixed external data fetch gating, HGVS c. fallback, gnomAD AF calc + v3 fallback
• Fixed CADD list responses and AlphaMissense mapping