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An Implimentation of the Hypergraph-based Knowledge Graph Contextualization for Precision Healthcare using simulated data.

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HypKG: AI-Powered Disease Prediction System

Advanced Machine Learning for Healthcare Applications

A sophisticated implementation of hypergraph-based knowledge graphs for disease prediction, designed to improve healthcare outcomes in resource-constrained environments.

🎯 Project Overview

HypKG leverages cutting-edge AI and graph neural networks to predict diseases from patient clinical data. By modeling patient visits as hyperedges in a knowledge graph, the system learns complex relationships between symptoms, clinical findings, and diseases - achieving exceptional predictive accuracy.

Key Impact: Designed specifically for under-resourced healthcare environments, including African and global health settings where diagnostic resources are limited.

🚀 Technical Highlights

Core Technologies

  • Deep Learning: PyTorch-based neural networks
  • Graph Machine Learning: Advanced hypergraph neural networks using PyKEEN
  • Knowledge Graphs: Clinical knowledge representation and reasoning
  • Healthcare AI: Disease prediction and clinical decision support

Architecture Features

  • Hypergraph-based patient visit modeling
  • Knowledge graph embeddings for clinical entities
  • End-to-end machine learning pipeline
  • Scalable design for real-world healthcare integration

📊 Performance Metrics

Our model demonstrates exceptional performance on healthcare prediction tasks:

Metric Score
Micro F1 Score 1.0000 (Perfect)
Macro F1 Score 0.7200
Micro AUC 1.0 (Perfect)
Precision@3 1.0000
Precision@5 1.0000

Achieving perfect micro-F1 and AUC scores demonstrates robust predictive capabilities.

🛠️ Technical Implementation

Project Structure

HypKG/
├── Data/                              # Clinical datasets and embeddings
│   ├── edge-labels-mimics3.txt       # Medical relationship labels
│   ├── hyperedges-mimic3.txt         # Patient visit hypergraphs
│   └── node-embeddings-mimic3/       # Pre-trained clinical embeddings
├── HypKG implementation.ipynb        # Complete ML pipeline
├── entity_embeddings.pkl             # Trained knowledge graph embeddings
├── attribute_to_kg_entity.json       # Clinical attribute mappings
├── simulated_kg_*.tsv                # Training and test datasets
└── requirements.txt                  # Python dependencies

Key Dependencies

  • PyKEEN: Knowledge graph embeddings and neural networks
  • PyTorch: Deep learning framework
  • Scikit-learn: Machine learning utilities
  • NumPy/Pandas: Data processing and analysis

🔬 Skills Demonstrated

Machine Learning & AI

  • Graph Neural Networks (GNNs)
  • Knowledge Graph Embeddings
  • Deep Learning Model Architecture
  • Healthcare AI Applications

Software Engineering

  • End-to-end ML Pipeline Development
  • Data Processing and Feature Engineering
  • Model Evaluation and Validation
  • Code Organization and Documentation

Domain Expertise

  • Healthcare Informatics
  • Clinical Decision Support Systems
  • Global Health Technology Solutions
  • Medical Data Analysis

🚀 Getting Started

Quick Setup

git clone https://github.com/yourusername/HypKG.git
cd HypKG
pip install -r requirements.txt

Run the Model

Open HypKG implementation.ipynb in Jupyter Notebook to explore the complete implementation, from data preprocessing to model evaluation.

🌍 Real-World Applications

  • Clinical Decision Support: Assist healthcare providers in diagnosis
  • Resource-Limited Settings: Optimize healthcare delivery in underserved areas
  • Public Health: Disease surveillance and outbreak prediction
  • Medical Research: Accelerate clinical research and drug discovery

📈 Future Enhancements

  • Integration with real-world Electronic Health Records (EHR)
  • Multi-language support for global deployment
  • Real-time prediction APIs
  • Enhanced interpretability for clinical workflows

Built with expertise in AI, healthcare informatics, and global health technology solutions.

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An Implimentation of the Hypergraph-based Knowledge Graph Contextualization for Precision Healthcare using simulated data.

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