MAxO (Medical Action Ontology) provides a structured vocabulary of medical actions including treatments, interventions, and diagnostic procedures. MAxO Annotations are curated annotations linking these medical actions to diseases and phenotypes.
Data is downloaded from: https://raw.githubusercontent.com/monarch-initiative/maxo-annotations/master/annotations/maxo-annotations.tsv
Each annotation row links a medical action (MAxO term) to a phenotype (HPO term), with an optional disease context and optional extension term that further specifies the action. The maxo_relation field determines the predicate:
| maxo_relation | Predicate |
|---|---|
| TREATS | biolink:ameliorates_condition |
| PREVENTS | biolink:preventative_for_condition |
| CONTRAINDICATED | biolink:contraindicated_in |
| INVESTIGATES | biolink:related_to |
| LACK OF OBSERVED RESPONSE | biolink:related_to |
| UNKNOWN | biolink:related_to |
Biolink Captured:
biolink:ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation- id (UUID)
- subject (MAxO term ID)
- subject_specialization_qualifier (extension ID, when present)
- predicate (mapped from maxo_relation, see above)
- original_predicate (raw maxo_relation value)
- object (HPO term ID)
- disease_context_qualifier (disease ID, when present)
- publications (citation)
- primary_knowledge_source (
infores:maxo) - aggregator_knowledge_source (
["infores:monarchinitiative"]) - knowledge_level (
knowledge_assertion) - agent_type (
manual_agent)
Carmody LC, Gargano MA, Toro S, Vasilevsky NA, Adam MP, Blau H, Chan LE, Gomez-Andres D, Horvath R, Kraus ML, Ladewig MS, Lewis-Smith D, Lochmuller H, Matentzoglu NA, Munoz-Torres MC, Schuetz C, Seitz B, Similuk MN, Sparks TN, Strauss T, Swietlik EM, Thompson R, Zhang XA, Mungall CJ, Haendel MA, Robinson PN. The Medical Action Ontology: A tool for annotating and analyzing treatments and clinical management of human disease. Med. 2023;4(12):913-927.e3. doi: 10.1016/j.medj.2023.10.003. PMID: 37963467
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